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Common side effects of painkillers may include drowsiness, constipation, dizziness, and nausea. It is important to follow prescribed dosages and consult a healthcare provider for any concerns, especially regarding the long-term use of stronger painkillers. Common side effects of painkillers may include drowsiness, constipation, dizziness, and nausea. It is important to follow prescribed dosages and consult a healthcare provider for any concerns, especially regarding the long-term use of stronger painkillers.These medications can include over-the-counter options like acetaminophen (Tylenol) and ibuprofen (Advil), which are commonly used for headaches,