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Norco 10/325 tablets works by altering the way the brain and nervous system respond to pain, providing relief from discomfort. The combination of hydrocodone and acetaminophen enhances pain management, with hydrocodone addressing the pain directly and acetaminophen adding to its effectiveness. Norco is available in various strengths, with typical dosages ranging from 5mg/325mg to 10mg/325mg of hydrocodone/acetaminophen.